缅北禁地

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Staff Profile

Professor David Thwaites

Emeritus Professor

Background

Position

Emeritus Professor, 缅北禁地 Biosciences Institute

Area of Expertise

Our main area of scientific investigation is to determine the physiological function of vertebrate and invertebrate membrane transporters (known as SLCs or Solute Carriers). The investigations range from molecular to whole organism and include analysis of the physiological and pathophysiological characteristics of epithelial transport in the mammalian small intestine and kidney, and the role of membrane transporters in nutrient uptake and symbiosis in blood-feeding and sap-feeding invertebrates.

Qualifications

Certificate in Teaching & Learning, 缅北禁地

PhD, Physiology, University of Liverpool

BSc (Hons), Physiological Sciences, 缅北禁地

Previous positions

Professor of Epithelial Physiology, Biosciences, 缅北禁地

Reader in Gastrointestinal Physiology, Cell & Molecular Biosciences, 缅北禁地

Lecturer, Physiological Sciences, 缅北禁地

Wellcome Trust Research Fellow, Physiological Sciences, 缅北禁地

European Molecular Biology Organization (EMBO) Fellow, Institute of Physiology, University of Zürich, Switzerland

Postdoctoral Research Associate, Physiological Sciences, 缅北禁地

Membership of Learned Societies

Fellow of The Physiological Society (FTPS)

Fellow of the British Pharmacological Society (FBPhS)

Royal Entomological Society

Natural History Society of Northumbria


Research

Research field

Membrane transport proteins are the gatekeepers of all cells and organelles, controlling influx and efflux of essential organic and inorganic solutes, drugs and excretory products. Each individual cell type possesses a unique, large and diverse complement of membrane transporters to enable that cell to interact with its environment to import and export all material essential for life.

Our research focusses on the physiological function of Solute Carrier (SLC) membrane transporters in two key scientific areas:

  • Epithelial transport in the mammalian small intestine and kidney
  • Nutrient uptake from diet and symbiosis in blood-feeding and sap-feeding invertebrates
Teaching

From October 2025, I will no longer be teaching undergraduate students. Over recent years, I taught the following courses at 缅北禁地.


Undergraduate Teaching

1997-2025 Module Leader & Lecturer PSC3011 Physiology of the Gastrointestinal Tract I (15 credits)

2015-2022 & 2024-2025 Module Leader PSC3012 Integrated Physiology (10 credits)

1997-2025 Lecturer PSC3012 Integrated Physiology

1997-2025 Undergraduate Project Supervisor CMB3000 Research Projects


Postgraduate Teaching

PhD supervisor of 17 PhD students


Previous Undergraduate Teaching, Module Leader & Leadership roles

2014-2019 Curriculum Chair, Physiological Sciences Degree Programme

2018-2022 Lecturer, PSC2018 Human Anatomy for Physiologists

2007-2022 Module Leader & Lecturer PSC3013 Physiology of the Gastrointestinal Tract II (15 credits)

2006-2007 Module Leader & Lecturer PSC3001 Physiology of the Gastrointestinal Tract (30 credits)

2002-2006 Module Leader & Lecturer PSC3020 Epithelia, Gut & Kidney (30 credits)

1997-2002 Module Leader & Lecturer PSC301 Gastrointestinal Physiology (15 credits)

1997-2003 Lecturer, Gastrointestinal Physiology, Stage 1 Bachelor of Dental Sciences (BDS)

1997-2017 Seminar Leader, Stage 1 Bachelor of Medical Sciences (MBBS)

1997-2003 Seminar Leader, Stage 1 BDS

1997-2000 Seminar Leader, Stage 1 BSc Physiology

1990-1996 Lecturer PSC301 Gastrointestinal Physiology

Publications

  • Articles

    • Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA, Amarosi L, Anderson CMH, Beart PM, Broer S, Dawson PA, Gyimesi G, Hagenbuch B, Hammond JR, Hancox JC, Hershfinkel M, Inui K-I, Kanai Y, Kemp S, Kunji ERS, Stewart G, Tavoulari S, Thwaites DT, Verri T. . British Journal of Pharmacology 2023, 180(S2), S374-S469.
    • Duncan RP, Anderson CMH, Thwaites DT, Luetje CW, Wilson ACC. . Proceedings of the National Academy of Sciences USA 2023, 120(43), e2308448120.
    • Anderson CMH, Edwards N, Watson AK, Althaus M, Thwaites DT. . Biomolecules 2022, 12(10), 1404.
    • Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Amarosi L, Anderson CMH, Beart PM, Broer S, Dawson PA, Hagenbuch B, Hammond JR, Inui KI, Kanai Y, Kemp S, Stewart G, Thwaites DT, Verri T. . British Journal of Pharmacology 2021, 178(S1), S412-S513.
    • Feng H, Edwards N, Anderson CMH, Althaus M, Duncan RP, Hsu Y-C, Luetje CW, Price DRG, Wilson ACC, Thwaites DT. . Proceedings of the National Academy of Sciences of the United States of America 2019, 116(32), 16003-16011.
    • Palazzolo L, Paravicini C, Laurenzi T, Adobati S, Saporiti S, Guerrini U, Gianazza E, Indiveri C, Anderson CMH, Thwaites DT, Eberini I. . SLAS Discovery 2019, 24(9), 928-938.
    • Major P, Sendra K, Dean P, Williams TA, Watson AK, Thwaites DT, Embley TM, Hirt RP. . eLife 2019, 8, e47037.
    • Edwards N, Anderson CMH, Conlon NJ, Watson AK, Hall RJ, Cheek TR, Embley TM, Thwaites DT. . Cellular and Molecular Life Sciences 2018, 75(5), 921-938.
    • Halbritter J, Baum M, Hynes AM, Rice SJ, Thwaites DT, Gucev ZS, Fisher B, Spaneas L, Porath JD, Braun DA, Wassner AJ, Nelson CP, Tasic V, Sayer JA, Hildebrandt F. . Journal of the American Society of Nephrology 2015, 26(3), 543-551.
    • Rhodes HL, Yarram L, Rice SJ, Tabaksert A, Edwards N, Hartley A, Woodward MN, Smithson SL, Tomson C, Welsh GI, Williams M, Thwaites DT, Sayer JA, Coward RJM. . Clinical Journal of the American Society of Nephrology 2015, 10(7), 1235-1245.
    • Edwards N, Rice SJ, Raman S, Hynes AM, Srivastava S, Moore I, Al-Hamed M, Xu Y, Santibanez-Koref M, Thwaites DT, Gale D, Sayer JA. . Clinical Kidney Journal 2015, 8(1), 113-119.
    • Rice SJ, Thwaites DT, Halbritter J, Sayer JA. . Medical & Surgical Urology 2014, 3(3), 1-2.
    • Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, Dautzenberg FM, Davenport AP, Dawson PA, Dent G, Dijksterhuis JP, Dollery CT, Dolphin AC, Donowitz M, Dubocovich ML, Eiden L, Eidne K, Evans BA, Fabbro D, Fahlke C, Farndale R, Fitzgerald GA, Fong TM, Fowler CJ, Fry JR, Funk CD, Futerman AH, Ganapathy V, Gaisnier B, Gershengorn MA, Goldin A, Goldman ID, Gundlach AL, Hagenbuch B, Hales TG, Hammond JR, Hamon M, Hancox JC, Hauger RL, Hay DL, Hobbs AJ, Hollenberg MD, Holliday ND, Hoyer D, Hynes NA, Inui KI, Ishii S, Jacobson KA, Jarvis GE, Jarvis MF, Jensen R, Jones CE, Jones RL, Kaibuchi K, Kanai Y, Kennedy C, Kerr ID, Khan AA, Klienz MJ, Kukkonen JP, Lapoint JY, Leurs R, Lingueglia E, Lippiat J, Lolait SJ, Lummis SC, Lynch JW, MacEwan D, Maguire JJ, Marshall IL, May JM, McArdle CA, McGrath JC, Michel MC, Millar NS, Miller LJ, Mitolo V, Monk PN, Moore PK, Moorhouse AJ, Mouillac B, Murphy PM, Neubig RR, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro MA, Parsons S, Pertwee RG, Petersen J, Pin JP, Poyner DR, Prigent S, Prossnitz ER, Pyne NJ, Pyne S, Quigley JG, Ramachandran R, Richelson EL, Roberts RE, Roskoski R, Ross RA, Roth M, Rudnick G, Ryan RM, Said SI, Schild L, Sanger GJ, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan CN, Sexton PM, Sibley DR, Siegel JM, Singh G, Sitsapesan R, Smart TG, Smith DM, Soga T, Stahl A, Stewart G, Stoddart LA, Summers RJ, Thorens B, Thwaites DT, Toll L, Traynor JR, Usdin TB, Vandenberg RJ, Villalon C, Vore M, Waldman SA, Ward DT, Willars GB, Wonnacott SJ, Wright E, Ye RD, Yonezawa A, Zimmermann M. . British Journal of Pharmacology 2013, 170(8), 1449-1458.
    • Conlon NJ, Edwards N, Anderson CMH, Cheek TR, Thwaites DT. . FASEB Journal 2013, 27, 732-735.
    • Thwaites DT. . Current Opinion in Pharmacology 2013, 13, 843-846.
    • Thwaites DT. . Journal of Physiology 2012, 590(24), 6255-6256.
    • Thwaites DT, Anderson CMH. . British Journal of Pharmacology 2011, 164(7), 1802-1816.
    • Edwards N, Anderson CMH, Gatfield KM, Jevons MP, Ganapathy V, Thwaites DT. . Biochimica et Biophysica Acta: Biomembranes 2011, 1808(1), 260-270.
    • Anderson CMH, Jevons M, Thangaraju M, Edwards N, Conlon NJ, Woods S, Ganapathy V, Thwaites DT. . Journal of Pharmacology and Experimental Therapeutics 2010, 332(1), 220-228.
    • Anderson CMH, Thwaites DT. . Physiology 2010, 25(6), 364-377.
    • Anderson CMH, Howard A, Walters JRF, Ganapathy V, Thwaites DT. . Journal of Physiology 2009, 587(4), 731-744.
    • Anderson CMH, Ganapathy V, Thwaites DT. . Journal of Physiology 2008, 586(17), 4061-4067.
    • Anderson CMH, Thwaites DT. . Biochimica et Biophysica Acta: Biomembranes 2007, 1768(7), 1822-1829.
    • Thwaites DT, Anderson CMH. . Experimental Physiology 2007, 92(4), 603-619.
    • Thwaites DT, Anderson CMH. . Biochimica et Biophysica Acta: Biomembranes 2007, 1768(2), 179-197.
    • Abbot EL, Grenade DS, Kennedy DJ, Gatfield KM, Thwaites DT. . British Journal of Pharmacology 2006, 147(3), 298-306.
    • Kennedy DJ, Gatfield KM, Winpenny JP, Ganapathy V, Thwaites DT. . British Journal of Pharmacology 2005, 144(1), 28-41.
    • Miyauchi S, Abbot EL, Zhuang L, Subramanian R, Ganapathy V, Thwaites DT. . Molecular Membrane Biology 2005, 22(6), 549-559.
    • Anderson CMH, Thwaites DT. . Journal of Cellular Physiology 2005, 204(2), 604-613.
    • Kennedy DJ, Raldua D, Thwaites DT. . Cellular and Molecular Life Sciences 2005, 62(14), 1621-1631.
    • Anderson CMH, Grenade DS, Boll M, Foltz M, Wake KA, Kennedy DJ, Munck LK, Miyauchi S, Taylor PM, Campbell FC, Munck BG, Daniel H, Ganapathy V, Thwaites DT. . Gastroenterology 2004, 127(5), 1410-1422.
    • Boll M, Foltz M, Anderson CMH, Oechsler C, Kottra G, Thwaites DT, Daniel H. . Molecular Membrane Biology 2003, 20(3), 261-269.
    • Chen Z, Kennedy DJ, Wake KA, Zhuang L, Ganapathy V, Thwaites DT. . Biochemical and Biophysical Research Communications 2003, 304(4), 747-754.
    • Chen Z, Fei Y-J Y, Anderson CMH, Wake K, Miyauchi S, Huang W, Thwaites DT, Ganapathy V. . Journal of Physiology 2003, 546(2), 349-361.
    • Anderson CMH, Mendoza ME, Kennedy DJ, Raldua D, Thwaites DT. . British Journal of Pharmacology 2003, 138(4), 564-573.
    • Kennedy DJ, Thwaites DT. . Journal of Physiology 2002, 539(supplement), 10P-11P.
    • Kennedy DJ, Leibach FH, Ganapathy V, Thwaites DT. . Pfluegers Archiv: European Journal of Physiology 2002, 445(1), 139-146.
    • Thwaites DT, Kennedy D, Raldua D, Anderson CMH, Mendoza ME, Bladen C, Simmons N. . Gastroenterology 2002, 122(5), 1322-1333.
    • Glanville M, Kingscote S, Thwaites DT, Simmons NL. . Pfluegers Archiv: European Journal of Physiology 2001, 443(1), 123-131.
    • Thwaites DT, Basterfield L, McCleave P, Carter S, Simmons NL. . British Journal of Pharmacology 2000, 129(3), 457-464.
    • Thwaites DT, Stevens BC. . Experimental Physiology 1999, 84(2), 275-284.
    • Thwaites DT, Ford D, Glanville M, Simmons NL. . Journal of Clinical Investigation 1999, 104(5), 629-635.
    • Marcaggi P, Thwaites DT, Deitmer JW, Coles JA. . European Journal of Neuroscience 1999, 11(1), 167-177.
    • Ford D, Thwaites D, Simmons N, Gilbert H, Hirst B. . Journal of Physiology 1998, 507(3), 697-706.
    • Thwaites DT. . Amino Acids 1997, 13(1), 49.
    • Thwaites DT, Markovich D, Murer H, Simmons NL. . Journal of Membrane Biology 1996, 151(3), 215-224.
    • Thwaites DT, McEwan GTA, Simmons NL. . Journal of Membrane Biology 1995, 145(3), 245-256.
    • Wenzel U, Thwaites DT, Daniel H. . British Journal of Pharmacology 1995, 116(7), 3021-3027.
    • Thwaites DT, McEwan GTA, Hirst BH, Simmons NL. . Biochimica et Biophysica Acta: Biomembranes 1995, 1234(1), 111-118.
    • Freeman TC, Bentsen BS, Thwaites DT, Simmons NL. . Pfluegers Archiv: European Journal of Physiology 1995, 430(3), 394-400.
    • Thwaites DT, Armstrong G, Hirst BH, Simmons NL. . British Journal of Pharmacology 1995, 115(5), 761-766.
    • Thwaites DT, Cavet M, Hirst BH, Simmons NL. . British Journal of Pharmacology 1995, 114(5), 981-986.
    • Thwaites DT, Hirst BH, Simmons NL. . British Journal of Pharmacology 1994, 113(3), 1050-1056.
    • Thwaites DT, McEwan GTA, Brown CDA, Hirst BH, Simmons NL. . Journal of Membrane Biology 1994, 140(2), 143-151.
    • Thwaites DT, Brown CDA, Hirst BH, Simmons NL. . Journal of Biological Chemistry 1993, 268(11), 7640-7642.
    • Thwaites DT, McEwan GTA, Hirst BH, Simmons NL. . Pfluegers Archiv: European Journal of Physiology 1993, 425(1-2), 178-180.
    • Thwaites DT, Simmons NL, Hirst BH. . Pharmaceutical Research 1993, 10(5), 667-673.
    • Thwaites DT, Hirst BH, Simmons NL. . Pharmaceutical Research 1993, 10(5), 674-681.
    • Thwaites DT, McEwan GTA, Brown CDA, Hirst BH, Simmons NL. . Journal of Biological Chemistry 1993, 268, 18438-18441.
    • Thwaites DT, Brown CDA, Hirst BH, Simmons NL. . Biochimica et Biophysica Acta: Biomembranes 1993, 1151(2), 237-245.
    • Thwaites DT, McEwan GTA, Cook MJ, Hirst BH, Simmons NL. . FEBS Letters 1993, 333(1-2), 78-82.
    • Thwaites DT, Hirst BH, Simmons NL. . Biochemical and Biophysical Research Communications 1993, 194(1), 432-438.

  • Book Chapter

    • Thwaites DT, Hirst BH, Simmons NL. . In: Molecular and Cellular Mechanisms of H<sup>+</sup> Transport. Heidelberg: Springer-Verlag, 1994, pp.283-296.

  • Editorial

    • Thwaites DT. . Journal of Physiology 2014, 592, 861-861.

  • Research Datasets/Databases

    • Anderson CMH, Thwaites DT. . 2023. Edinburgh: University of Edinburgh.
    • Thwaites DT, Verri T. . 2023. IUPHAR/BPS Guide to Pharmacology CITE.

  • Reviews

    • Anderson CM, Thwaites DT. . IUPHAR/BPS Guide to Pharmacology CITE 2021, 2021(3).
    • Thwaites DT, Verri T. . IUPHAR/BPS Guide to Pharmacology CITE 2021, 2021(3).
    • Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA, Anderson CMH, Bröer S, Dawson P, Hagenbuch B, Hammond JR, Hancox J, Inui KI, Kanai Y, Kemp S, Thwaites DT, Verri T. . British Journal of Pharmacology 2019, 176(S1), S397-S493.
    • Anderson CMH, Thwaites DT. . IUPHAR/BPS Guide to Pharmacology CITE 2019, 2019(4).
    • Thwaites DT, Verri T. . IUPHAR/BPS Guide to Pharmacology CITE 2019, 2019(4).
    • Alexander SP, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA, Abbracchio MP, Aldrich R, Al-Hosaini K, Arumugam TV, Attali B, Bäck M, Barnes NM, Bathgate R, Beart PM, Becirovic E, Bettler B, Biel M, Birdsall NJ, Blaho V, Boison D, Bräuner-Osborne H, Bröer S, Bryant C, Burnstock G, Calo G, Catterall WA, Ceruti S, Chan SL, Chandy KG, Chazot P, Chiang N, Chun JJ, Chung JJ, Clapham DE, Clapp L, Connor MA, Cox HM, Davies P, Dawson PA, Decaen P, Dent G, Doherty P, Douglas SD, Dubocovich ML, Fong TM, Fowler CJ, Frantz A, Fuller P, Fumagalli M, Futerman AH, Gainetdinov RR, Gershengorn MA, Goldin A, Goldstein S, Goudet C, Gregory K, Grissmer S, Gundlach AL, Hagenbuch B, Hamann J, Hammond JR, Hancox JC, Hanson J, Hanukoglu I, Hay DL, Hobbs AJ, Hollenberg AN, Holliday ND, Hoyer D, Ijzerman AP, Inui KI, Irving AJ, Ishii S, Jacobson KA, Jan LY, Jarvis MF, Jensen R, Jockers R, Kaczmarek LK, Kanai Y, Karnik S, Kellenberger S, Kemp S, Kennedy C, Kerr ID, Kihara Y, Kukkonen J, Larhammar D, Leach K, Lecca D, Leeman S, Leprince J, Lolait SJ, Macewan D, Maguire JJ, Marshall F, Mazella J, Mcardle CA, Michel MC, Miller LJ, Mitolo V, Mizuno H, Monk PN, Mouillac B, Murphy PM, Nahon JL, Nerbonne J, Nichols CG, Norel X, Offermanns S, Palmer LG, Panaro MA, Papapetropoulos A, Perez-Reyes E, Pertwee RG, Pintor S, Pisegna JR, Plant LD, Poyner DR, Prossnitz ER, Pyne S, Ramachandran R, Ren D, Rondard P, Ruzza C, Sackin H, Sanger G, Sanguinetti MC, Schild L, Schiöth H, Schulte G, Schulz S, Segaloff DL, Serhan CN, Singh KD, Slesinger PA, Snutch TP, Sobey CG, Stewart G, Stoddart LA, Summers RJ, Szabo C, Thwaites D, Toll L, Trimmer JS, Tucker S, Vaudry H, Verri T, Vilargada JP, Waldman SA, Ward DT, Waxman SG, Wei AD, Willars GB, Wong SS, Woodruff TM, Wulff H, Ye RD, Yung Y, Zajac JM. . British Journal of Pharmacology 2017, 174(S1), S1-S16.