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Staff Profile

Professor Julie Irving

Professor of Experimental Haematology

  • Email: julie.irving@ncl.ac.uk
  • Telephone: +44 (0) 191 208 2234
  • Fax: +44 (0) 191 208 4301
  • Personal Website: /medical-sciences/people/profile/julieirving.html
  • Address: Translational and Clinical Research Institute, Faculty of Medical Sciences
    缅北禁地

    Wolfson Childhood Cancer Research Centre, Herschel Building, Level 6, Brewery Lane, 缅北禁地 upon Tyne
    Tyne and Wear
Background

I am a Molecular/Cell Biologist specialising in novel therapies for the treatment of haematological malignancies, principally childhood acute lymphoblastic leukaemia.


Academic background

BSc Hons Physiological Sciences and PhD in cell biology, both 缅北禁地


Google scholar:

SCOPUS:


Research

While the improvement in the treatment of childhood acute lymphoblastic leukaemia (ALL) over the last fifty years has been a resounding success, clinical challenges remain. They include the need for alternative therapies for relapsed disease and those at high risk of relapse due to persistent disease. In addition, treatment is prolonged, is associated with short and long term toxicity issues and some children may be cured with lesser treatment. The long term clinical goal may be to replace one or more of the standard therapeutic agents with a targeted, less toxic drug.

I lead a research team which aims to address these challenges by using advanced technologies to optimise therapy in children with ALL. We perform minimal residual disease quantitation by flow cytometry which is fundamental for stratifying treatment but importantly are leaders in the field in terms of qualitative analyses of these persisting cells. We have made significant advances in understanding the underlying drug resistant phenotype of these persisting cells and how it may be therapeutically exploited. Thus future treatment protocols may include novel drugs which target these residual cells in children with high levels of persisting disease and consequently at high risk of relapse. In terms of novel therapies for relapsed ALL, my group has shown that mutation of genes activating the RAS/RAF/MEK/ERK pathway is the most common genetic abnormality and have identified  MEK inhibitors as a potential novel therapeutic option which would be applicable to around 40% of children. Data from my laboratory has led to a phase I/II clinical trial of the MEK inhibitor selumetinib in combination with dexamethasone for children and adults with relapsed RAS-driven ALL.  

Teaching
I am the deputy director of education for the Translational and Clinical Research Institute and deputy Curriculum Chair  for Biomedical Sciences. I am also the module leader for BMS3010- Genetics and human disease and for an e-learning master module CHS8009-Molecular Pathology in Stratified Healthcare 

I lecture on :-

BGM3024

The Molecular Basis of Cancer

BGM3061

Genetic variation in common disease

BMS3008

Integrated Biomedical Sciences

BMS3010

Genetics and Human Disease

BMS3012

Cancer Biology and Therapy

PED3006

Carcinogenesis and Anticancer Drugs

Publications
  • Tandon S, Visser R, Astwood E, Payne J, Gray J, Wheeler L, Irving J, Virgo P. . British Journal of Haematology 2022, 196(3), e34-e39.
  • Eckert C, Parker C, Moorman AV, Irving JA, Kirschner-Schwabe R, Groeneveld-Krentz S, Revesz T, Hoogerbrugge P, Hancock J, Sutton R, Henze G, Chen-Santel C, Attarbaschi A, Bourquin J-P, Sramkova L, Zimmermann M, Krishnan S, von Stackelberg A, Saha V. . European Journal of Cancer 2021, 151, 175-189.
  • Mansur M, Furness CL, Enshaei A, Nakjang S, Alpar D, Colman SM, Minto L, Irving J, Poole BV, Noronha LP, Savola S, Iqbal S, Gribben J, Pombo-de-Oliveira MS, Ford TM, Greaves M, van Delft F. . Cancer Medicine 2021, 10(14), 4864-4873.
  • Doan M, Case M, Masic D, Hennig H, McQuin C, Caicedo J, Singh S, Goodman A, Wolkenhauer O, Summers H, Jamieson D, van Delft FW, Filby A, Carpenter A, Rees P, Irving J. . Cytometry A 2020, 97(4), 407-414.
  • Matheson EC, Thomas H, Case M, Blair H, Jackson RK, Masic D, Veal G, Halsey C, Newell DR, Vormoor J, Irving JAE. . Haematologica 2019, 104(9), 1804-1811.
  • Jackson RK, Liebich M, Berry P, Errington J, Liu J, Parker C, Moppett J, Samarasinghe S, Hough R, Rowntree C, Goulden NJ, Vora A, Kearns PR, Saha V, Hempel G, Irving JAE, Veal GJ. . European Journal of Cancer 2019, 120, 75-85.
  • Parker C, Krishnan S, Hamadeh L, Irving JAE, Kuiper RP, Revesz T, Hoogerbrugge P, Hancock J, Sutton R, Moorman AV, Saha V. . The Lancet Haematology 2019, 6(4), e204-e216.
  • Sinclair PB, Ryan S, Bashton M, Hollern S, Hanna R, Case M, Schwalbe EC, Schwab CJ, Cranston RE, Young BD, Irving JAE, Vora AJ, Moorman AV, Harrison CJ. . Leukemia 2019, 33, 1881-1894.
  • Hrusak O, De Haas V, Stancikova J, Vakrmanova B, Janotova I, Mejstrikova E, Capek V, Trka J, Zaliova M, Luks A, Bleckmann K, Moricke A, Irving J, Konatkowska B, Alexander TB, Inaba H, Schmiegelow K, Stokley S, Zemanova Z, Moorman AV, Rossi JG, Felice MS, Dalla-Pozza L, Morales J, Dworzak M, Buldini B, Basso G, Campbell M, Cabrera ME, Marinov N, Elitzur S, Izraeli S, Luria D, Feuerstein T, Kolenova A, Svec P, Kreminska O, Rabin KR, Polychronopoulou S, Da Costa E, Marquart HV, Kattamis A, Ratei R, Reinhardt D, Choi JK, Schrappe M, Stary J. . Blood 2018, 132(3), 264-276.
  • Norden J, Pearce K, Irving J, Collin M, Wang X, Wolff D, Kolb HJ, Socie G, Kuzmina Z, Greinix H, Holler E, Rocha V, Gluckman E, Hromadnikova I, Dickinson AM. . International Journal of Immunogenetics 2018, 45(5), 247-256.
  • Vijayakrishnan J, Kumar R, Henrion MYR, Moorman AV, Rachakonda PS, Hosen I, da Silva Filho MI, Holroyd A, Dobbins SE, Koehler R, Thomsen H, Irving JA, Allan JM, Lightfoot T, Roman E, Kinsey SE, Sheridan E, Thompson PD, Hoffmann P, Nöthen MM, Heilmann-Heimbach S, Jockel KH, Greaves M, Harrison CJ, Bartram CR, Schrappe M, Stanulla M, Hemminki K, Houlston RS. . Leukemia 2017, 31(3), 573-579.
  • Vormoor B, Veal GJ, Griffin MJ, Boddy AV, Irving J, Minto L, Case M, Banerji U, Swales KE, Tall JR, Moore AS, Toguchi M, Acton G, Dyer K, Schwab C, Harrison CJ, Grainger JD, Lancaster D, Kearns P, Hargrave D, Vormoor J. . Pediatric Blood & Cancer 2017, 64(6), e26351 1-4.
  • Dixon ZA, Nicholson L, Zeppetzauer M, Matheson E, Sinclair P, Harrison CJ, Irving JAE. . Haematologica 2017, 102(4), 736-745.
  • Frismantas V, Dobay MP, Rinaldi A, Tchinda J, Dunn SH, Kunz J, Richter-Pechanska P, Marovca B, Pail O, Jenni S, Diaz-Flores E, Chang BH, Brown TJ, Collins RH, Uhrig S, Balasubramanian GP, Bandapalli OR, Higi S, Eugster S, Voegeli P, Delorenzi M, Cario G, Loh ML, Schrappe M, Stanulla M, Kulozik AE, Muckenthaler MU, Saha V, Irving JA, Meisel R, Radimerski T, Von Stackelberg A, Eckert C, Tyner JW, Horvath P, Bornhauser BC, Bourquin J-P. . Blood 2017, 129(11), e26-e37.
  • Cave H, Caye A, Strullu M, Aladjidi N, Vignal C, Ferster A, Mechinaud F, Domenech C, Pierri F, Contet A, Cacheux V, Irving J, Kratz C, Clavel J, Verloes A. . European Journal of Medical Genetics 2016, 59(3), 173-178.
  • Weiland J, Pal D, Case M, Irving J, Ponthan F, Koschmieder S, Heidenreich O, von Stackelberg A, Eckert C, Vormoor J, Elder A. . Leukemia 2016, 30(9), 1920–1923.
  • Irving JAE, Enshaei A, Parker CA, Sutton R, Kuiper RP, Erhorn A, Minto L, Venn NC, Law T, Yu J, Schwab C, Davies R, Matheson E, Davies A, Sonneveld E, den Boer ML, Love SB, Harrison CJ, Hoogerbrugge PM, Revesz T, Saha V, Moorman AV. . Blood 2016, 128(7), 911-922.
  • Jackson RK, Irving JAE, Veal GJ. . British Journal of Haematology 2016, 173(1), 13-24.
  • Williams MT, Yousafzai YM, Elder A, Rehe K, Bomken S, Frishman-Levy L, Tavor S, Sinclair P, Dormon K, Masic D, Perry T, Weston VJ, Kearns P, Blair H, Russell LJ, Heidenreich O, Irving JA, Izraeli S, Vormoor J, Graham GJ, Halsey C. . Blood 2016, 127(16), 1998-2006.
  • Irving JAE. . In: Conquering RAS: From Biology to Cancer Therapy. Elsevier Inc, 2016, pp.61-78.
  • Ryan SL, Matheson E, Grossmann V, Sinclair P, Bashton M, Schwab C, Towers W, Partington M, Elliott A, Minto L, Richardson S, Rahman T, Keavney B, Skinner R, Bown N, Haferlach T, Vandenberghe P, Haferlach C, Santibanez-Koref M, Moorman AV, Kohlmann A, Irving JA, Harrison CJ. . Leukemia 2016, 30, 1824-1831.
  • Irving JAE. . British Journal of Haematology 2016, 172(5), 655-666.
  • Trahair TN, Lock RB, Sutton R, Sia KCS, Evans K, Richmond J, Law T, Venn NC, Irving JA, Moore S, Nievergall E, Dang P, Heatley SL, White DL, Revesz T. . Bone Marrow Transplantation 2016, 51(9), 1279-1282.
  • Hrusak O, Luks A, Janotova I, Mejstrikova E, Vaskova M, Bleckmann K, Konatkowska B, Irving J, Polgarova K, Inaba H, Schmiegelow K, Rossi JG, Felice MS, Dalla-Pozza L, Morales J, Sartor M, Dworzak M, Moricke A, Campbell M, Cabrera ME, Marinov N, Elitzur S, Izraeli S, De Haas V, Kolenova A, Svec P, Kreminska E, Stokley S, Polychronopoulou S, da Costa E, Marquart HV, Kattamis A, Ratel R, Reinhardt D, Jackson K, Moorman AV, Schrappe M, Stary J. . In: 57th ASH Annual Meeting and Exposition. 2015, Orlando, USA: American Society of Hematology.
  • Yousafzai YM, Williams MTS, Bhatti S, Cousins A, Rehe K, Bomken S, Sinclair P, Weston VJ, Russell LJ, Heidenreich O, Irving JAE, Vormoor J, Graham GJ, Halsey C. . In: 55th Annual Scientific Meeting of the British Society for Haematology. 2015, Edinburgh, UK: Wiley.
  • Moorman AV, Irving J, Enshaei A, Parker CA, Sutton R, Kuiper R, Erhorn A, Minto L, Venn NC, Law T, Yu J, Schwab C, Davies R, Sonneveld E, den Boer ML, Love SB, Harrison CJ, Hoogerbrugge PM, Revesz T, Saha V. . In: 20th Congress of the European Hematology Association. 2015, Vienna: Ferrata Storti Foundation.
  • Dixon Z, Irving JAE, Nicholson L. . In: 57th ASH Annual Meeting 2015. 2015, Orlando, USA: American Society of Hematology.
  • Dixon Z, Nicholson L, Irving J. . In: 57th Annual Meeting and Exposition of the American Society of Hematology (ASH). 2015, Orlando, FL, USA: American Society of Hematology.
  • Fordham SE, Cole M, Irving JA, Allan JM. . Leukemia 2015, 29(2), 491-494.
  • Nicholson L, Mavin E, Minto L, Irving J, Dickinson A, Wang XN. . In: 57th Annual Meeting and Exposition of the American Society of Hematology (ASH). 2015, Orlando, FL, USA: American Society of Hematology.
  • Nicholson L, Mavin E, Minto L, Irving J, Dickinson A, Wang XN. . In: 57th ASH Annual Meeting 2015. 2015, Orlando, USA: American Society of Hematology.
  • Nicholson L, Evans C, Matheson E, Minto L, Keilty C, Sanichar M, Case M, Schwab C, Williamson D, Rainer J, Harrison C, Kofler R, Hall AG, Rednern CPF, Wheaton AD, Irving JAE. . British Journal of Haematology 2015, 171(4), 595–605.
  • Irving J, Matheson E, Minto L, Blair H, Case M, Halsey C, Swidenbank I, Ponthan F, Kirschner-Schwabe R, Groeneveld-Krentz S, Hof J, Allan J, Harrison C, Vormoor J, von Stackelberg A, Eckert C. . Blood 2015, 125(5), 890-890.
  • Vijayakrishnan J, Henrion M, Moorman AV, Fiege B, Kumar R, da Silva MI, Holroyd A, Koehler R, Thomsen H, Irving JA, Allan JM, Lightfoot T, Roman E, Kinsey SE, Sheridan E, Thompson PD, Hoffmann P, Nothen MM, Muhleisen TW, Eisele L, Bartram CR, Schrappe M, Greaves M, Hemminki K, Harrison CJ, Stanulla M, Houlston RS. . Scientific Reports 2015, 5, 15065.
  • Eswaran J, Sinclair P, Heidenreich O, Irving J, Russell LJ, Hall A, Calado DP, Harrison CJ, Vormoor J. . Leukemia 2015, 29(8), 1623-1631.
  • Fordham SE, Cole M, Irving JA, Allan JM. . In: AACR Annual Meeting 2014. 2014, San Diego, CA: American Association for Cancer Research.
  • Irving J, Matheson E, Minto L, Blair H, Case M, Halsey C, Swidenbank I, Ponthan F, Kirschner-Schwabe R, Groeneveld-Krentz S, Hof J, Allan J, Harrison C, Vormoor J, von Stackelberg A, Eckert C. . Blood 2014, 124(23), 3420-3430.
  • Knight T, Irving JAE. . Frontiers in Oncology 2014, 4, 160.
  • Rehe K, Wilson K, Bomken S, Williamson D, Irving J, den Boer ML, Stanulla M, Schrappe M, Hall AG, Heidenreich O, Vormoor J. . EMBO Molecular Medicine 2013, 5(1), 38-51.
  • Chubb D, Weinhold N, Broderick P, Chen B, Johnson DC, Forsti A, Vijayakrishnan J, Migliorini G, Dobbins SE, Holroyd A, Hose D, Walker BA, Davies FE, Gregory WA, Jackson GH, Irving JA, Pratt G, Fegan C, Fenton JAL, Neben K, Hoffmann P, Nothen MM, Muhleisen TW, Eisele L, Ross FM, Straka C, Einsele H, Langer C, Dorner E, Allan JM, Jauch A, Morgan GJ, Hemminki K, Houlston RS, Goldschmidt H. . Nature Genetics 2013, 45(10), 1221-1225.
  • Migliorini G, Fiege B, Hosking FJ, Ma Y, Kumar R, Sherborne AL, da Silva MI, Vijayakrishnan J, Koehler R, Thomsen H, Irving JA, Allan JM, Lightfoot T, Roman E, Kinsey SE, Sheridan E, Thompson P, Hoffmann P, Nothen MM, Muhleisen TW, Eisele L, Zimmermann M, Bartram CR, Schrappe M, Greaves M, Stanulla M, Hemminki K, Houlston RS. . Blood 2013, 122(19), 3298-3307.
  • Nicholson L, Knight T, Matheson E, Minto L, Case M, Sanichar M, Bomken S, Vormoor J, Hall A, Irving J. . Genes, Chromosomes & Cancer 2012, 51(3), 250-256.
  • Enciso-Mora V, Hosking FJ, Sheridan E, Kinsey SE, Lightfoot T, Roman E, Irving JAE, Tomlinson IPM, Allan JM, Taylor M, Greaves M, Houlston RS. . Leukemia 2012, 26(10), 2212-2215.
  • Fiser K, Sieger T, Schumich A, Wood B, Irving J, Mejstrikova E, Dworzak MN. . Cytometry Part A 2012, 81A(1), 25-34.
  • Hunter JE, Willmore E, Irving JAE, Hostomsky Z, Veuger SJ, Durkacz BW. . Oncogene 2012, 31(2), 251-264.
  • de Brito LR, Batey MA, Zhao Y, Squires MS, Maitland H, Leung HY, Hall AG, Jackson G, Newell DR, Irving JAE. . Leukemia Research 2011, 35(9), 1233-1240.
  • Fordham SE, Matheson EC, Scott K, Irving JAE, Allan JM. . Leukemia 2011, 25(6), 1046-1049.
  • Rand V, Parker H, Russell LJ, Schwab C, Ensor H, Irving J, Jones L, Masic D, Minto L, Morrison H, Ryan S, Robinson H, Sinclair P, Moorman A, Strefford J, Harrison CJ. . Blood 2011, 117(25), 6848-6855.
  • Al-Balool HH, Weber D, Liu Y, Wade M, Guleria K, Nam PL, Clayton J, Rowe W, Coxhead J, Irving J, Elliott DJ, Hall AG, Santibanez-Koref M, Jackson MS. . Genome Research 2011, 21(11), 1788-1799.
  • Squires M, Ward G, Saxty G, Berdini V, Cleasby A, King P, Angibaud P, Perera T, Fazal L, Ross D, Jones CG, Madin A, Benning RK, Vickerstaffe E, O'Brien A, Frederickson M, Reader M, Hamlett C, Batey MA, Rich S, Carr M, Miller D, Feltell R, Thiru A, Bethell S, Devine LA, Graham BL, Pike A, Cosme J, Lewis EJ, Freyne E, Lyons J, Irving J, Murray C, Newell DR, Thompson NT. . Molecular Cancer Therapeutics 2011, 10(9), 1542-1552.
  • Nicholson L, Evans C, Matheson EC, Minto L, Keilty C, Schwab C, Harrison CJ, Hall AG, Redfern C, Whetton A, Irving J. . In: Blood: 53rd Annual Meeting and Exposition of the American Society of Hematology (ASH). 2011, San Diego, California, USA: American Society of Hematology.
  • Ryan SL, Rand V, Schwab C, Morrison H, Matheson E, Minto L, Rahman T, Keavney B, Bown N, Skinner R, Schnittger S, Santibanez-Koref M, Grossmann V, Kohlmann A, Irving J, Harrison CJ. . In: 53rd Annual Meeting and Exposition of the American Society of Hematology (ASH). 2011, San Diego, California, USA: American Society of Hematology.
  • Pratt G, Fenton JAL, Allsup D, Fegan C, Morgan GJ, Jackson G, Sunter NJ, Hall AG, Irving JAE, Allan JM. . British Journal of Haematology 2010, 150(3), 371-373.
  • Peasland A, Matheson E, Hall A, Irving J. . Leukemia Research 2010, 34(3), 322-327.
  • Jiang XY, Grant H, Stebbing J, Foroni L, Craddock C, Griffiths M, Clark RE, Brien SO, Khorashad JS, Gerrard G, Wang LH, Irving J, Wang M, Karran L, Dyer MJS, Forrest DL, Page K, Eaves CJ, Woolfson A. . In: 52nd Annual Meeting of the American Society of Hematology. 2010, Orlando, FL: Blood: American Society of Hematology.
  • Grant H, Jiang X, Stebbing J, Foroni L, Craddock C, Griffiths M, Clark RE, O'Brien S, Khorashad JS, Gerrard G, Wang L, Irving JAE, Wang M, Karran L, Dyer MJS, Forrest D, Page K, Eaves CJ, Woolfson A. . Leukemia 2010, 24(10), 1817-1821.
  • Jiang XY, Grant H, Stebbing J, Foroni L, Craddock C, Griffiths M, Clark RE, O'Brien S, Khorashad JS, Gerrard G, Wang LH, Irving J, Wang M, Karran L, Dyer MJS, Forrest DL, Page K, Eaves CJ, Woolfson A. . In: Blood: 52nd Annual Meeting of the American Society of Hematology. 2010, Orlando, Florida, USA: American Society of Hematology.
  • Fordham SE, Matheson EC, Scott K, Irving J, Allan JM. . In: Blood: American Society of Hematology Annual Meeting. 2010, Orlando, Florida, USA: American Society of Hematology.
  • Fordham SE, Matheson EC, Scott K, Irving J, Allan JM. . In: Blood: 52nd Annual Meeting of the American Society of Hematology. 2010, Orlando, Florida, USA: American Society of Hematology.
  • Hosking FJ, Papaemmanuil E, Sheridan E, Kinsey SE, Lightfoot T, Roman E, Irving JAE, Allan JM, Taylor M, Tomlinson IP, Greaves M, Houlston RS. . Blood 2010, 115(22), 4472-4477.
  • Rehe K, Wilson K, Bomken S, McNeill H, Stanulla M, Den Boer ML, Irving J, Heidenreich O, Vormoor J. . In: Blood: 52nd Annual Meeting of the American Society of Hematology. 2010, Orlando, Florida, USA: American Society of Hematology.
  • Rehe K, Wilson K, Bomken S, McNeill H, Stanulla M, Den Boer ML, Irving J, Heidenreich O, Vormoor J. . In: Blood: 52nd Annual Meeting of the American Society of Hematology. 2010, Orlando, Florida, USA: American Society of Hematology.
  • Hosking FJ, Leslie S, Dilthey A, Moutsianas L, Wang Y, Dobbins SE, Papaemmanuil E, Sheridan E, Kinsey SE, Lightfoot T, Roman E, Irving JA, Allan JM, Taylor M, Greaves M, McVean G, Houlston RS. . Blood 2010, 117(5), 1633-1640.
  • Best A, Matheson E, Minto L, Hall AG, Irving JAE. . Leukemia Research 2010, 34(8), 1098-1102.
  • Nicholson L, Hall AG, Redfern CP, Irving J. . Leukemia Research 2010, 34(10), 1366-1373.
  • Sherborne AL, Hosking FJ, Prasad RB, Kumar R, Koehler R, Vijayakrishnan J, Papaemmanuil E, Bartram CR, Stanulla M, Schrappe M, Gast A, Dobbins SE, Ma Y, Sheridan E, Taylor M, Kinsey SE, Lightfoot T, Roman E, Irving JAE, Allan JM, Moorman AV, Harrison CJ, Tomlinson IP, Richards S, Zimmermann M, Szalai C, Semsei AF, Erdelyi DJ, Krajinovic M, Sinnett D, Healy J, Neira AG, Kawamata N, Ogawa S, Koeffler HP, Hemminki K, Greaves M, Houlston RS. . Nature Genetics 2010, 42(6), 492-494.
  • Sulong S, Moorman AV, Irving JAE, Strefford JC, Konn ZJ, Case MC, Minto L, Barber KE, Parker H, Wright SL, Stewart ARM, Bailey S, Bown NP, Hall AG, Harrison CJ. . Blood 2009, 113(1), 100-107.
  • Russell LJ, Capasso M, Vater I, Akasaka T, Bernard OA, Calasanz MJ, Chandrasekaran T, Chapiro E, Gesk S, Griffiths M, Guttery DS, Haferlach C, Harder L, Heidenreich O, Irving JAE, Kearney L, Nguyen-Khac F, Machado L, Minto L, Majid A, Moorman AV, Morrison H, Rand V, Strefford JC, Schwab CJ, Tonnies H, Dyer MJ, Siebert R, Harrison CJ. . Blood 2009, 114(13), 2688-2698.
  • Irving JAE, Jesson J, Virgo P, Case MC, Minto CLJ, Eyre L, Noel N, Johansson U, Macey M, Knotts L, Helliwell M, Davies P, Whitby L, Barnett D, Hancock J, Goulden N, Lawson S. . Haematologica 2009, 94(6), 870-874.
  • Wilson K, Case M, Minto L, Bailey S, Bown N, Jesson J, Lawson S, Vormoor J, Irving J. . Haematologica 2009, 95(4), 679-683.
  • Gruber G, Carlet M, Türtscher E, Meister B, Irving J, Ploner C, Kofler R. . Leukemia 2009, 23(4), 820-823.
  • Papaemmanuil E, Hosking FJ, Vijayakrishnan J, Price A, Olver B, Sheridan E, Kinsey SE, Lightfoot T, Roman E, Irving JAE, Allan JM, Tomlinson IP, Taylor M, Greaves M, Houlston RS. . Nature Genetics 2009, 41(9), 1006-1010.
  • Paulsson K, An Q, Moorman AV, Parker H, Molloy G, Davies T, Griffiths MJ, Ross FM, Irving JAE, Harrison CJ, Young BD, Strefford JC. . British Journal of Haematology 2009, 144(6), 838-847.
  • Brito JLR, Walker B, Jenner M, Dickens NJ, Brown NJM, Ross FM, Avramidou A, Irving JAE, Gonzalez D, Davies FE, Morgan GJ. . Haematologica 2009, 94(1), 78-86.
  • Syed AA, Halpin C, Irving JAE, Unwin NC, White M, Bhopal RS, Redfern CPF, Weaver JU. . Clinical Endocrinology 2008, 68(6), 879-884.
  • Bungaro, S., Irving, J.A.E., Tussiwand, R., Mura, R., Minto, C.L.J., Molteni, C., Citterio, M., Hall, A.G., Biondi, A., Cazzaniga, G. . Leukemia 2008, 22(1), 208-211.
  • le Viseur C, Hotfilder M, Bomken S, Wilson K, Röttgers S, Schrauder A, Rosemann A, Irving JAE, Stam R, Shultz L, Harbott J, Jürgens H, Schrappe M, Pieters R, Vormoor HJ. . Cancer Cell 2008, 14(1), 47-58.
  • Wilson K, Rehe K, Bomken S, Case M, Shultz L, Irving J, Vormoor J. . In: Blood: 50th Annual Meeting of the American Society of Hematology. 2008, San Francisco, California, USA: American Society of Hematology.
  • Case MC, Matheson E, Minto L, Hassan R, Harrison CJ, Bown NP, Bailey S, Vormoor J, Hall AG, Irving JAE. . Cancer Research 2008, 68(16), 6803-6809.
  • Parker H, An Q, Barber K, Case MC, Davies TL, Konn Z, Stewart A, Wright S, Griffiths M, Ross FM, Moorman AV, Hall AG, Irving JAE, Harrison CJ, Strefford JC. . Genes, Chromosomes and Cancer 2008, 47(12), 1118-1125.
  • An Q, Wright SL, Konn ZJ, Matheson E, Minto L, Moorman AV, Parker H, Griffiths M, Ross FM, Davies T, Hall AG, Harrison CJ, Irving JA, Strefford JC. . Proceedings of the National Academy of Sciences 2008, 105(44), 17050-17054.
  • Matheson EC, Hogarth LA, Case MC, Irving JAE, Hall AG. . Carcinogenesis 2007, 28(6), 1341-1346.
  • Syed, A.A., Irving, J.A.E., Redfern, C.P.F., Hall, A.G., Unwin, N.C., White, M.J.R., Bhopal, R.S., Weaver, J.U. . Obesity 2006, 14(5), 759-764.
  • Sulong, S., Irving, J.A.E., Case, M.C., Minto, C.L.J., Bown, N., Bailey, S., Harrison, C., Hall, A.G. . Blood 2006, 108(11).
  • Schmidt S, Irving JAE, Minto CLJ, Matheson E, Nicholson L, Ploner A, Parson W, Kofler A, Amort M, Erdel M, Hall AG, Kofler R. . The FASEB Journal 2006, 20(14), E2087-E2097.
  • Irving, J.A.E., Minto, C.L.J., Matheson, E., Case, M.C., Bailey, S., Bown, N.P., Hassan, R., Harrison, C., Hall, A.G. . Blood 2006, 108(11), 160B-161B.
  • Meier, M., den Boer, M., Hall, A.G., Irving, J.A.E., Passier, M., Minto, C.L.J., van Wering, E., Janka-Schaub, G., Pieters, R. . Leukemia 2006, 20(3), 527.
  • Cazzaniga G, Irving J, Citterio M, Bungaro S, Tussiwand R, Mura R, Hall AG, Biondi A. . In: 47th Annual Meeting of the American Society of Hematology. 2005, Atlanta, Georgia, USA: Blood: American Society of Hematology.
  • Velangi M, Matheson E, Hall AG, Irving JAE. . In: Brown RD; Ho PJ, ed. Multiple Myeloma. Totowa, N.J: Humana Press, Inc, 2005, pp.269-77.
  • Irving, J.A.E., Minto, C.L.J., Bailey, S., Hall, A.G. . Cancer Research 2005, 65(21), 9712-9718.
  • Irving JAE, Bloodworth LC, Bown NP, Case MC, Hogarth LA, Hall AG. . Cancer Research 2005, 65(8), 3053-3058.
  • Meier, M., den Boer, M., Hall, A.G., Irving, J.A.E., Passier, M., Minto, C.L.J., van Wering, E., Janka-Schaub, G., Pieters, R. . Leukemia 2005, 19(11), 1887-1895.
  • Sulong, S., Case, M.C., Minto, C.L.J., Wilkins, B., Hall, A.G., Irving, J. . British Journal of Haematology 2005, 130(6), 964-965.
  • Velangi MR, Matheson EC, Taylor PRA, Jackson GH, Hall AG, Irving JAE. . Leukemia 2004, 18(3), 658-659.
  • Velangi MR, Matheson EC, Morgan GJ, Jackson GH, Taylor PRA, Hall AG, Irving JAE. . Carcinogenesis 2004, 25(10), 1795-1803.
  • Syed, A.A., Irving, J.A.E., Redfern, C.P.F., Hall, A.G., Unwin, N.C., White, M., Bhopal, R., Alberti, K., Weaver, J.U. . Journal of Clinical Endocrinology and Metabolism 2004, 89(1), 232-235.
  • Irving JAE, O'Brien S, Lennard A, Minto CLJ, Lin F, Hall AG. . Clinical Chemistry 2004, 50(7), 1233-1237.
  • Hall AG, Coulthard SA, Irving JAE. . Expert Review of Molecular Diagnostics 2003, 3(1), 13-16.
  • Hall AG, Irving JAE. . Expert Review of Anticancer Therapy 2002, 2(3), 239-240.
  • Thomas MJ, Irving JAE, Lennard AL, Proctor SJ, Taylor PRA. . Journal of Clinical Pathology 2001, 54(6), 491-3.
  • Middleton PG, Norden J, Levett DL, Levasseur M, Miller S, Irving JAE, Wood A, Reid MM, Taylor PRA, Proctor SJ. . Medical and Pediatric Oncology 2000, 34(2), 106-110.
  • Irving JAE, Lennard AL, Storey N, Conn J, Dunn J, Oliver K, Proctor SJ, Dickinson AM. . Leukemia 1999, 13(6), 944-949.
  • Thomas MJ, Irving JA, Lennard AL, Proctor SJ, Taylor PRA. Validation of the Hasford score in a demographic study in CGL. Blood 1999, 94, 4466.
  • Proctor SJ, Taylor PRA, Irving JAE, Bown N. Acute lymphoblastic leukaemia in adults in the Northern Health Region of England: A 14 year population based study. British Journal of Haematology 1998, 102, 229-229.
  • Lennard, A. L., Storey, N., Dickinson, A. M., Irving, J. A. E., Rowe, D., Conn, J. S., Proctor, S. J. . Leukemia 1998, 12(5), 746-752.
  • Irving, J. A. E., Finney, R. D., Lennard, A. L., Proctor, S. J. . Bone Marrow Transplantation 1998, 21(3), 323-325.
  • Irving JAE, Cain G, Howard M, Angus B, Taylor PRA, Cattan AR. . Journal of Clinical Pathology 1998, 51(10), 776-780.
  • Irving JAE, Lennard AL, Dickinson A. . Blood 1997, 90(10), 957-957.
  • Rowe D, Devaraj PE, Irving JAE, Hogarth LA, Hall AG, Turner GE. . British Journal of Haematology 1996, 94(1), 133-135.
  • Irving JAE, Cain G, Parr A, Howard M, Angus B, Cattan AR. . Journal of Clinical Pathology 1996, 49(3), 258-259.
  • Ademokun AJ, Irving JAE, Maung ZT, Howard MR, Proctor SJ, Jackson GH. . Leukemia 1995, 9(1), 225-226.
  • Thompson S, Latham JAE, Turner GA. . Clinica Chimica Acta 1987, 167(2), 217-223.