Staff Profile
Dr Nicholas Brittain
Research Associate
- Email: nicholas.brittain@ncl.ac.uk
- Personal Website: /medical-sciences/people/profile/nicholasbrittain.html
- Address: Herschel Building
Wolfson Childhood Cancer Research Centre
缅北禁地 Centre for Cancer
Herschel Building, Level 6
Brewery Lane
缅北禁地 upon Tyne NE1 7RU
ORCID
https://orcid.org/0009-0005-9103-7996
Current position
Postdoctoral Research Associate, Wolfson Childhood Cancer Research Centre - Leukaemia Epigenomics and Enhancer Dysregulation (LEGEND) group led by Dr Lisa Russell
Experience/Expertise
Molecular biology:
- Plasmid cloning
- RNA, DNA and protein analysis
- CRISPR systems
Cell biology:
- 2D cell culture
- 3D cell culture
- Primary cell culture
- Lentiviral transduction/generation of transgenic cells
Bioinformatics:
- Transcriptomics
- Proteomics
- Epigenomics
- R/Linux
Qualifications
2023: PhD Molecular Oncology (CRUK funded), 缅北禁地
2016: MSc Translational Oncology, University of Hull
2013: BSc Biomedical Science, University of Warwick
Previous positions
2023 - 2025: Scientist, Newcells Biotech Ltd
2019 - 2023: Postgraduate Researcher, 缅北禁地 Centre for Cancer Urology Research/Solid Tumour Target Discovery group
2016 - 2019: Scientific Officer, CRUK Manchester Institute Clinical & Experimental Pharmacology group (now part of the CRUK National Biomarker Centre)
Professional memberships
British Association for Cancer Research (BACR)
European Association for Cancer Research (EACR)
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Articles
- Brittain N, Paschalis A, Nelson R, Adamson B, Walker L, Duncan R, Smith GR, McGill S, Burchmore RJ, Bogdan D, Jiménez-Vacas JM, Welti J, Yuan W, Robson CN, Rescigno P, Luzzi S, Sharp A, de Bono J, Gaughan L. Splicing factor TRA2B enhances synthesis of androgen receptor variant AR-V7 in prostate cancer cells. The Journal of Clinical Investigation 2026, 136(7).
- Paschalis A, Figueiredo I, Bogdan D, Lundberg A, Santos R, Gurel B, Taha T, Longoria O, Ferreira A, Bertan C, Brittain N, Nelson R, Walker L, Neeb A, Welti J, Yuan W, Mitsopoulos C, Plymate SR, Haffner MC, Sowalsky AG, Carreira S, Sharp A, Gaughan L, de Bono J. Androgen receptor splice variant 7 expression levels distinguish AR-mutated from nonmutated metastatic castration-resistant prostate cancers. The Journal of Clinical Investigation 2026, 136(7).
- Walker L, Duncan R, Adamson B, Kendall H, Brittain N, Luzzi S, Jones D, Chaytor L, Peel S, Crafter C, O'Neill DJ, Gaughan L. . Molecular Cancer Research 2024, 22(12), 1128-1142.
- Adamson B, Brittain N, Walker L, Duncan R, Luzzi S, Rescigno P, Smith GR, McGill S, Burchmore RJS, Willmore E, Hickson I, Robson CN, Bogdan D, Jimenez-Vacas JM, Paschalis A, Welti J, Yuan W, McCracken SR, Heer R, Sharp A, de Bono J, Gaughan L. . Journal of Clinical Investigation 2023, 133(22), e169200.
- Poujade FA, Mannion A, Brittain N, Theodosi A, Beeby E, Leszczynska K, Hammond E, Greenman J, Cawthorne C, Pires IM. WSB-1 regulates the metastatic potential of hormone receptor negative breast cancer. British Journal of Cancer 2018, 118(9), 1229–1237.