Vascular Biology and Medicine
We conduct research into fundamental vascular mechanisms and the treatment of cardiovascular disease.
Our research investigates the fundamental mechanisms involved in vascular and myocardial homeostasis and inflammation. We aim to develop new treatments and diagnostics for cardiovascular diseases including coronary heart disease, heart failure, cardiovascular ageing, and microvascular disease.
There is important unmet medical need for an interdisciplinary study of cardiovascular diseases mechanisms, effective identification of therapeutic targets, novel therapeutic regimens, and the development of novel diagnostics and methods of vascular assessment.
Our expertise spans from basic science to clinical medicine. Our strategy is to build bridges among the 缅北禁地 Institutes and local NHS Trusts. We collaborate with major stakeholders (biotech and pharmaceutical industries) and develop strategies to address major vascular health problems.
Research impact
Our research shows that amyloid-beta levels may be a key indicator of cardiovascular disease. We aim to develop a simple blood test to identify most at-risk patients so that preventative measures can be put in place and death rates reduced.
Our team has explored the formation of senescent cells, also known as , in a preclinical model. These cells are damaged and can cause neighbouring cells to become senescent. We have uncovered their formation and identified possible reversal mechanisms to .
We are investigating . While the output of blood from the heart improves pressure builds up in the lungs. The pump does not respond to the demands of exercise in the same way as a normal heart.
We have partnered with Kancera AB and secured 拢1.7M to run the FRACTAL clinical trial. This will test if Kand567, a new drug which blocks Fractalkine, can be used to .
We have shown that and maintenance of the adult vasculature. Endoglin is regulated during angiogenesis, and its depletion leads to arteriovenous malformations.
Cardiovascular Immunology
Research topics include:
- RNA metabolism and vascular inflammation
- T-cell biology in ischemia/reperfusion injury in acute myocardial infarction
Key References
Gladka M, Stellos K.
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Cardiovascular Research (2021) DOI: 10.1093/cvr/cvaa338
Spray L, Park C, Cormack S, Mohammad A, Panahi P, Boag S, Bennaceur K, Sopova K, Richardson GD, Stangl V, Rech L, Rainer PP, Ramos GC, Hofmann U, Stellos K, Spyridopoulos I.
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Frontiers in Immunology (2021) DOI: 10.3389/fimmu.2021.605857
Vlachogiannis NI, Gatsiou A, Silvestris DA, Stamatelopoulos K, Tektonidou MG, Gallo A, Sfikakis PP, Stellos K.
Journal of Autoimmunity (2020) DOI: 10.1016/j.jaut.2019.102329
Coelho-Lima J, Mohammed A, Cormack S, Jones S, Ali A, Panahi P, Barter M, Bagnall A, Ali S, Young D, Spyridopoulos I.
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Clinical Chemistry (2019) DOI: 10.1373/clinchem.2019.308353
Leisegang MS, Fork C, Josipovic I, Richter FM, Preussner J, Hu J, Miller MJ, Epah J, Hofmann P, G眉nther S, Moll F, Valasarajan C, Heidler J, Ponomareva Y, Freiman TM, Maegdefessel L, Plate KH, Mittelbronn M, Uchida S, K眉nne C, Stellos K, Schermuly RT, Weissmann N, Devraj K, Wittig I, Boon RA, Dimmeler S, Pullamsetti SS, Looso M, Miller FJ Jr, Brandes RP.
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Circulation (2017) DOI: 10.1161/CIRCULATIONAHA.116.026991
Stellos K, Gatsiou A, Stamatelopoulos K, Perisic Matic L, John D, Lunella FF, Ja茅 N, Rossbach O, Amrhein C, Sigala F, Boon RA, F眉rtig B, Manavski Y, You X, Uchida S, Keller T, Boeckel JN, Franco-Cereceda A, Maegdefessel L, Chen W, Schwalbe H, Bindereif A, Eriksson P, Hedin U, Zeiher AM, Dimmeler S.
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Nature Medicine (2016) DOI 10.1038/nm.4172
Spyridopoulos I, Martin-Ruiz C, Hilkens C, Yadegarfar ME, Isaacs J, Jagger C, Kirkwood T, von Zglinicki T.
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Aging Cell (2016) DOI: 10.1111/acel.12430
Boag SE, Das R, Shmeleva EV, Bagnall A, Egred M, Howard N, Bennaceur K, Zaman A, Keavney B, Spyridopoulos I. .
The Journal of Clinical Investigation (2015) DOI: 10.1172/JCI80055
Cardiovascular Ageing
Research topics include:
- amyloid-beta in cardiovascular ageing and disease
- senescence in cardiovascular inflammation and ageing
- telomere length shortening and telomerase biology
Key references
Lambrinoudaki I, Delialis D, Georgiopoulos G, Tual-Chalot S, Vlachogiannis NI, Patras R, Aivalioti E, Armeni E, Augoulea A, Tsoltos N, Soureti A, Stellos K, Stamatelopoulos K.
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Thrombosis and Haemostasis (2021) DOI 10.1055/s-0040-1721144
Tektonidou MG, Kravvariti E, Vlachogiannis NI, Georgiopoulos G, Mantzou A, Sfikakis PP, Stellos K, Stamatelopoulos K.
. Rheumatology (Oxford) (2021) DOI 10.1093/rheumatology/keaa548
Stakos DA, Stamatelopoulos K, Bampatsias D, Sachse M, Zormpas E, Vlachogiannis NI, Tual-Chalot S, Stellos K.
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Journal of the American College of Cardiology (2020) DOI 10.1016/j.jacc.2019.12.033
Anderson R, Lagnado A, Maggiorani D, Walaszczyk A, Dookun E, Chapman J, Birch J, Salmonowicz H, Ogrodnik M, Jurk D, Proctor C, Correia-Melo C, Victorelli S, Fielder E, Berlinguer-Palmini R, Owens A, Greaves LC, Kolsky KL, Parini A, Douin-Echinard V, LeBrasseur NK, Arthur HM, Tual-Chalot S, Schafer MJ, Roos CM, Miller JD, Robertson N, Mann J, Adams PD, Tchkonia T, Kirkland JL, Mialet-Perez J, Richardson GD, Passos JF.
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EMBO (2019) DOI: 10.15252/embj.2018100492
Stamatelopoulos K, Mueller-Hennessen M, Georgiopoulos G, Sachse M, Boeddinghaus J, Sopova K, Gatsiou A, Amrhein C, Biener M, Vafaie M, Athanasouli F, Stakos D, Pateras K, Twerenbold R, Badertscher P, Nestelberger T, Dimmeler S, Katus HA, Zeiher AM, Mueller C, Giannitsis E, Stellos K.
. Annals of Internal Medicine (2018) DOI 10.7326/M17-1540
Stamatelopoulos K, Pol CJ, Ayers C, Georgiopoulos G, Gatsiou A, Brilakis ES, Khera A, Drosatos K, de Lemos J, Stellos K.
Amyloid-beta (1-40) peptide and subclinical cardiovascular disease in the general population: the Dallas Heart Study.
Journal of the American College of Cardiology (2018) DOI: 10.1016/j.jacc.2018.06.027
Heart Failure
Research topics include:
- diagnostics and pharmacotherapy
- myocardial recovery in patients with left ventricular assist devices
- ischemia/reperfusion injury in heart transplantation
Key references
Wang L, MacGowan GA, Ali S, Dark J.
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The Journal of Heart and Lung Transplantation (2021) DOI 10.1016/j.healun.2020.10.004
Rushton S, Parameshwar J, Lim S, Dar O, Callan P, Al-Attar N, Tsui S, MacGowan GA.
The introduction of a super-urgent heart allocation scheme in the UK: a two-year review.
The Journal of Heart and Lung Transplantation (2020) DOI: 10.1016/j.healun.2020.06.013
Okwose N, O'brien N, Charman S, Cassidy S, Brodie D, Bailey K, MacGowan GA, Jakovljevic DG, Avery L. .
BMJ Open (2020) DOI 10.1136/bmjopen-2019-036382
Walaszczyk A, Dookun E, Redgrave R, Tual-Chalot S, Victorelli S, Spyridopoulos I, Owens A, Arthur HM, Passos JF, Richardson GD.
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Aging Cell (2019) DOI 10.1111/acel.12945
Jakovljevic DG, Yacoub MH, Schueler S, MacGowan AG, Velicki L, Seferovic PM, Hothi S, Tzeng BT, Brodie DA, Birks EJ, Tan LB.
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Journal of the American College of Cardiology (2017) DOI 10.1016/j.jacc.2017.02.018
Cardiovascular Therapeutics
Research topics include:
- drug discovery and preclinical testing of new therapeutic compounds
- clinical trials on patients with cardiovascular disease
- development of new surgical interventions
Key references
Maier R, Bawamia B, Bennaceur K, Dunn S, Marsay L, Amoah R, Kasim A, Filby A, Austin D, Hancock H, Spyridopoulos I.
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JMIR Research Protocols (2020) DOI 10.2196/19456
Cormack S, Mohammed A, Panahi P, Das R, Steel AJ, Chadwick T, Bryant A, Egred M, Stellos K, Spyridopoulos I, Capri I.
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British Journal of Clinical Pharmacology (2020) DOI 10.1111/bcp.14252
Dookun E, Walaszczyk A, Redgrave R, Palmowski P, Tual鈥�Chalot S, Suwana A, Chapman J, Jirkovsky E, Donastorg Sosa L, Gill E, Yausep O, Santin Y, Mialet鈥怭erez J, Owens WA, Grieve D, Spyridopoulos I, Taggart M, Arthur HM, Passos JF, Richardson GD.
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Aging Cell (2020) DOI: 10.1111/acel.13249
Zaman A, de Winter R, Kogame N, Chang C, Modolo R, Spitzer E, Tonino P, Hofma S, Zurakowski A, Smits C, Prokopczuk J, Moreno R, Choudhury A, Petrov I, Cequier A, Kukreja N, Hoye A, Iniguez A, Ungi I, Serra A, Gil R, Walsh S, Tonev G, Mathur A, Merkely B, Colombo A, Ijsselmuiden S, Soliman O, Kaul U, Onuma Y, Serruys P.
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Lancet (2019) DOI 10.1016/S0140-6736(18)32467-X
Windecker S, Latib A, Kedhi E, Kirtane AJ, Kandzari DE, Mehran R, Price MJ, Abizaid A, Simon DI, Worthley SG, Zaman A, Hudec M, Poliacikova P, Abdul Ghapar AKB, Selvaraj K, Petrov I, Mylotte D, Pinar E, Moreno R, Fabbiocchi F, Pasupati S, Kim HS, Aminian A, Tie C, Wlodarczak A, Hur SH, Marx SO, Jankovic I, Brar S, Bousquette L, Liu M, Stone GW; ONYX ONE Investigators.
Polymer-based or polymer-free stents in patients at high bleeding risk: ONYX ONE.
The New England Journal of Medicine (2019) DOI: 10.1056/NEJMoa1910021
Laina A, Gatsiou A, Georgiopoulos G, Stamatelopoulos K, Stellos K.
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Frontiers in Physiology (2018) DOI: 10.3389/fphys.2018.00953
Aortic and Vascular Disease
Research topics include:
- characterize the vascular involvement in amyloidosis and multiple myeloma
- understand the mechanism leading to and treatments for aortic aneurysm
- study the role of blood vessel, development, formation, and angiogenesis in cardiovascular disease
- understand the genetics underlying congenital heart defects
- develop novel cardiovascular and microvascular assessment and treatment technologies
- understand the causes of vascular dementia and depression in late life
Key references
Allen J, Liu H, Iqbal S, Zheng D, Stansby, G.
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Physiological Measurement (2021) DOI: 10.1088/1361-6579/abf9f3
Kastritis E, Laina A, Georgiopoulos G, Gavriatopoulou M, Papanagnou ED, Eleutherakis-Papaiakovou E, Fotiou D, Kanellias N, Dialoupi I, Makris N, Manios E, Migkou M, Roussou M, Kotsopoulou M, Stellos K, Terpos E, Trougakos IP, Stamatelopoulos K, Dimopoulos MA.
Carfilzomib-induced endothelial dysfunction, recovery of proteasome activity, and prediction of cardiovascular complications: a prospective study.
Leukemia (2021) DOI: 10.1038/s41375-021-01141-4
Tual-Chalot S, Garcia-Collado M, Redgrave RE, Singh E, Davison B, Park C, Lin H, Luli S, Jin Y, Wang Y, Lawrie A, Jakobsson L, Arthur HM.
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Circulation Research (2020) DOI: 10.1161/CIRCRESAHA.119.315974
Allen J, O鈥橲ullivan J, Stansby G, Murray A.
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Physiological Measurement (2020) DOI 10.1088/1361-6579/ab9b67
Nandhra S, Scott E, Boyan L, Williams R, McCaslin J.
The interplay between Preoperative anaemia and post-operative blood transfusion on survival following fenestrated aortic aneurysm repair.
Annals of Vascular Surgery (2020) DOI: 10.1016/j.avsg.2020.06.040
Stamatelopoulos K, Georgiopoulos GA, Athanasouli F, Nikolaou PE, Lykka M, Roussou M, Gavriatopoulou M, Laina A, Trakada G, Charakida M, Delialis D, Petropoulos I, Pamboukas C, Manios E, Karakitsou M, Papamichael C, Gatsiou A, Lambrinoudaki IV, Terpos E, Stellos K, Andreadou I, Dimopoulos MA, Kastritis E.
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Circulation Research (2019) DOI: 10.1161/CIRCRESAHA.119.314862
Phillips HM, Stothard CA, Shaikh Qureshi WM, Kousa AI, BrionesLeon JA, Khasawneh RR, Sanders R, O'Loughlin C, Mazzotta S, Dodds R, Seidel K, Bates T, Nakatomi M, Cockell SJ, Schneider JE, Mohun TJ, Maehr R, Kist R, Peters H, Bamforth SD.
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Development (2019) DOI: 10.1242/dev.177618
Bano A, Gan Addison C, Narayanan K, Weaver J, Tsatlidis V, Razvi S.
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The Journal of Clinical Endocrinology & Metabolism (2018) DOI: 10.1210/jc.2018-01738
Collaborative Research
- understanding biological and environmental factors regulating normal heart and blood vessel development and function and examining their impact on lifecourse and healthcourse trajectories
- understanding how changes in regeneration and stem cell activity contributes to cardiovascular disease
Key references
Oldershaw R, Owens WA, Sutherland R, Linney M, Liddle R, Magana L, Lash GE, Gill J, Richardson GD, Meeson A, Human cardiac mesenchymal stem cell-like cells, a novel cell population with therapeutic potential.
Stem Cells and Development (2019) DOI: 10.1089/scd.2018.0170
Palmowski P, Watson R, Europe-Finner GN, Karolczak-Bayatti M, Porter A, Treumann A, Taggart MJ.
The Generation of a Comprehensive Spectral Library for the Analysis of the Guinea Pig Proteome by SWATH-MS.
Proteomics (2019) DOI 10.1002/pmic.201900156
Baruch N, Burgess J, Pillai M, Allan CL.
Treatment for depression comorbid with dementia.
Evidence-based Mental Health (2019) DOI 10.1136/ebmental-2019-300113
Nicholson CJ, Sweeney M, Robson SC, Taggart MJ.
Estrogenic vascular effects are diminished by chronological aging.
Scientific Reports (2017) DOI 10.1038/s41598-017-12153-5
Theme leadership
Dr Gavin Richardson is our Theme Lead. Guy MacGowan and Ioakim Spyridopoulos are the Deputy Theme Leads.
We provide research-led teaching in cardiovascular health and disease at all levels. Ioakim Spyridopoulos is our Education Lead.
Early career researchers interested in collaborating, please contact Sandip Nandhra.
Professional Administration Services are provided by Ye Liu.
We are a supportive and inclusive community. Our theme EDI lead is Simon Tual-Chalot.
Immune cells contribute to injury after myocardial infarction.
Cultured senescence cell used for drug screening.
Magnetic resonance imaging and pressure and volume loops to study heart function.
Vascular network of the retina.
Dr Esha Singh supporting the BHF at the Great North Run.